Safety and Pharmacokinetics of JAK/ROCK Inhibitor in Healthy Volunteers

In BRG we are just starting Study for Healthy People with an Immune Drug - Part B. The aim of the following clinical trial is to determine safety and pharmacokinetic parameters in healthy volunteers after oral administration of Janus kinases and Rho-kinases inhibitor (JAK/ROCKi), called CPL409116.Janus kinase (JAK) inhibitors are a new class of small molecule drugs that modulate inflammatory pathways by blocking one or more JAK receptors. In recent years, JAK inhibitors have emerged as a new option for the treatment of various inflammatory diseases, including rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, skin disorders and others. CPL409116 inhibits JAK1 and JAK3 with less inhibitory activity against JAK2 and Tyk2. Inhibition of these kinases decreases inflammatory cytokine release which in turn decreases lymphocyte activation and proliferation. Moreover, CPL409116 blocks Rho-kinases (ROCKs), which are involved in diverse cellular processes including actin cytoskeleton organization, cell adhesion and motility, proliferation, apoptosis as well as smooth muscle contraction.  Dual inhibition of JAK/ROCK kinases may be beneficial for patients suffering from fibrotic complications of inflammatory disease. More information about the study you can find on

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31st Great Final of WOŚP

31st Great Final of Wielka Orkiestra Świątecznej Pomocy.

Lets play till the end of the world and one day longer!

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6th anniversary

This week we celebrate our 6th anniversary. Together with our CEO, clinical team and company's friends, we had a pleasure of being at Aga Zaryan's concert and fancy diner.

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We are constantly improving our knowledge to assure the best possible quality of our services.

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Medical Guide Where to Treat 2022

On 29th of April, a special thematic supplement was published in the Polska The Times and newspaper - Medical Guide Where to Treat 2022...

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